This presentation describes novel approaches to successfully deploy Data Mesh solutions with a focus on IBM zSystems, specifically Db2 for z/OS and other zSystems data. A Data Mesh – underpinned with a Data Fabric architecture – views data primarily as organized around domain owners who create business-focused data products, which can be aggregated and consumed across distributed consumers, organizations, and LoBs in a self-service and shopping-for-data fashion. Focusing on intelligent cataloguing with IBM Watson Knowledge Catalog and its new integration with Db2 Data Gate, we describe key AI-based Data Mesh concepts, such as automated metadata enrichment, data quality assessments, establishing a data marketplace, intelligent information integration, active metadata exploitation, and leveraging the digital exhaust.